/* * This code is generated by BioUML FrameWork * for BIOMD0000000003.xml diagram at 2008.03.20 15:03:14 */ import biouml.plugins.simulation.ae.NewtonSolver; import biouml.plugins.simulation.java.JavaBaseModel; import ru.biosoft.math.MathRoutines; public class BIOMD0000000003 extends JavaBaseModel { /* * Write rules to calculate equation parameters */ private void __internalVarInitFunc_0(double time, double[] x) { V1 = x[0]*VM1*Math.pow((x[0] + Kc), -1.0); V3 = x[1]*VM3; } /* * Write rules to calculate equation parameters excluding internal variables. */ public void __internalRateVarInitFunc_0(double time, double[] x) { rate_reaction1 = cell*reaction1_vi; rate_reaction2 = x[0]*cell*reaction2_kd; rate_reaction3 = x[0]*cell*reaction3_vd*x[2]*Math.pow((x[0] + reaction3_Kd), -1.0); rate_reaction4 = cell*(1 + -1.0*x[1])*V1*Math.pow((reaction4_K1 + -1.0*x[1] + 1), -1.0); rate_reaction5 = cell*x[1]*reaction5_V2*Math.pow((reaction5_K2 + x[1]), -1.0); rate_reaction6 = cell*V3*(1 + -1.0*x[2])*Math.pow((reaction6_K3 + -1.0*x[2] + 1), -1.0); rate_reaction7 = cell*reaction7_V4*x[2]*Math.pow((reaction7_K4 + x[2]), -1.0); } public void Init() { initialValues = getInitialValues(); /* * Initialize variables */ cell = 1.0; // initial value of $cell Kc = 0.5; // initial value of Kc VM1 = 3.0; // initial value of VM1 VM3 = 1.0; // initial value of VM3 reaction1_vi = 0.025; // initial value of reaction1_vi reaction2_kd = 0.01; // initial value of reaction2_kd reaction3_Kd = 0.02; // initial value of reaction3_Kd reaction3_vd = 0.25; // initial value of reaction3_vd reaction4_K1 = 0.0050; // initial value of reaction4_K1 reaction5_K2 = 0.0050; // initial value of reaction5_K2 reaction5_V2 = 1.5; // initial value of reaction5_V2 reaction6_K3 = 0.0050; // initial value of reaction6_K3 reaction7_K4 = 0.0050; // initial value of reaction7_K4 reaction7_V4 = 0.5; // initial value of reaction7_V4 } /* * Model variables initial values */ protected double rate_reaction1; protected double rate_reaction2; protected double rate_reaction3; protected double rate_reaction4; protected double rate_reaction5; protected double rate_reaction6; protected double rate_reaction7; protected double cell; protected double Kc; protected double V1; protected double V3; protected double VM1; protected double VM3; protected double reaction1_vi; protected double reaction2_kd; protected double reaction3_Kd; protected double reaction3_vd; protected double reaction4_K1; protected double reaction5_K2; protected double reaction5_V2; protected double reaction6_K3; protected double reaction7_K4; protected double reaction7_V4; public double[] extendResult(double time,double [] x) { this.time = time; __internalVarInitFunc_0(time, x); double[] y = new double[5]; y[0] = x[0]; y[1] = x[1]; y[2] = x[2]; y[3] = V1; y[4] = V3; return y; } public double[] getInitialValues() { double [] x = new double[3]; this.time = 0.0; x[0] = 0.01; // - $"cell.C" x[1] = 0.01; // - $"cell.M" x[2] = 0.01; // - $"cell.X" __internalVarInitFunc_0(time, x); __internalRateVarInitFunc_0(time, x); return x; } /* * code for algebraic rules calculations */ /* * end of code for algebraic rules calculations */ protected void calculateRates(double time, double[] x) { __internalVarInitFunc_0(time, x); __internalRateVarInitFunc_0(time, x); } /* * calculate dy/dt for 'BIOMD0000000003.xml' model */ public void __internalDyDt_0(double time, double [] x, double[] result) { result[0] = +rate_reaction1-rate_reaction2-rate_reaction3; result[1] = +rate_reaction4-rate_reaction5; result[2] = +rate_reaction6-rate_reaction7; } protected double [] calculateResult(double time, double[] x) { double[] result = new double[3]; __internalDyDt_0(time, x, result); return result; } public double[] dy_dt(double time, double[] x) { this.time = time; calculateRates( time,x ); return calculateResult( time,x ); } } // class ...