/* * This code is generated by BioUML FrameWork * for BIOMD0000000047.xml diagram at 2008.03.20 15:04:26 */ import biouml.plugins.simulation.ae.NewtonSolver; import biouml.plugins.simulation.java.JavaBaseModel; import ru.biosoft.math.MathRoutines; public class BIOMD0000000047 extends JavaBaseModel { /* * Write rules to calculate equation parameters */ private void __internalVarInitFunc_0(double time, double[] x) { n = n0*(Math.exp(-kbN*time) + kappa*(1 - Math.exp(-kbN*time))); p1 = p11 + p12*n/(K1 + n); p2 = x[0]/(K2 + x[0]); } /* * Write rules to calculate equation parameters excluding internal variables. */ public void __internalRateVarInitFunc_0(double time, double[] x) { rate_Jch = Jch_Fch_0*p1*p2*x[2]; rate_Jleak = Jleak_Fleak; rate_Jpump = Jpump_Fpump_0*x[0]/(Jpump_Kpump + x[0]); } public void Init() { initialValues = getInitialValues(); /* * Initialize variables */ Jch_Fch_0 = 8.0; // initial value of Jch_Fch_0 Jleak_Fleak = 0.5; // initial value of Jleak_Fleak Jpump_Fpump_0 = 2.0; // initial value of Jpump_Fpump_0 Jpump_Kpump = 0.1; // initial value of Jpump_Kpump K1 = 5.0; // initial value of K1 K2 = 0.7; // initial value of K2 K3 = 0.7; // initial value of K3 k31 = 0.5; // initial value of k31 kappa = 5.0; // initial value of kappa kbN = 0.5; // initial value of kbN n = 1.0; // initial value of n n0 = 1.0; // initial value of n0 p11 = 0.2; // initial value of p11 p12 = 0.8; // initial value of p12 } /* * Model variables initial values */ protected double rate_Jch; protected double rate_Jleak; protected double rate_Jpump; protected double Jch_Fch_0; protected double Jleak_Fleak; protected double Jpump_Fpump_0; protected double Jpump_Kpump; protected double K1; protected double K2; protected double K3; protected double k31; protected double kappa; protected double kbN; protected double n; protected double n0; protected double p1; protected double p11; protected double p12; protected double p2; protected double time; public double[] extendResult(double time,double [] x) { this.time = time; __internalVarInitFunc_0(time, x); double[] y = new double[6]; y[0] = x[0]; y[1] = x[1]; y[2] = n; y[3] = p1; y[4] = p2; y[5] = x[2]; return y; } public double[] getInitialValues() { double [] x = new double[3]; this.time = 0.0; x[0] = 0.0; // - $"Cytosol.Ca_Cyt" x[1] = 0.0; // - $"Cytosol.Endoplasmic_Reticulum.CaER" x[2] = 0.95; // - p3 __internalVarInitFunc_0(time, x); __internalRateVarInitFunc_0(time, x); return x; } /* * code for algebraic rules calculations */ /* * end of code for algebraic rules calculations */ protected void calculateRates(double time, double[] x) { __internalVarInitFunc_0(time, x); __internalRateVarInitFunc_0(time, x); } /* * calculate dy/dt for 'BIOMD0000000047.xml' model */ public void __internalDyDt_0(double time, double [] x, double[] result) { result[0] = +rate_Jch+rate_Jleak-rate_Jpump; result[1] = -rate_Jch-rate_Jleak+rate_Jpump; result[2] = -(k31*x[0]*x[2]) + k31*K3*(1 - x[2]); } protected double [] calculateResult(double time, double[] x) { double[] result = new double[3]; __internalDyDt_0(time, x, result); return result; } public double[] dy_dt(double time, double[] x) { this.time = time; calculateRates( time,x ); return calculateResult( time,x ); } } // class ...