/* * This code is generated by BioUML FrameWork * for BIOMD0000000098.xml diagram at 2008.03.20 15:08:34 */ import biouml.plugins.simulation.ae.NewtonSolver; import biouml.plugins.simulation.java.JavaBaseModel; import ru.biosoft.math.MathRoutines; public class BIOMD0000000098 extends JavaBaseModel { /* * Write rules to calculate equation parameters */ /* * Write rules to calculate equation parameters excluding internal variables. */ public void __internalRateVarInitFunc_0(double time, double[] x) { rate_R0 = cytosol*v0; rate_R1 = cytosol*v1*beta; rate_R2 = cytosol*(Vm2*Math.pow(x[0], n)/(Math.pow(K2, n) + Math.pow(x[0], n))); rate_R3 = store*(Vm3*Math.pow(x[1], m)*Math.pow(x[0], p)/((Math.pow(Kr, m) + Math.pow(x[1], m))*(Math.pow(Ka, p) + Math.pow(x[0], p)))); rate_R_eff = cytosol*k*x[0]; rate_Rf = store*kf*x[1]; } public void Init() { initialValues = getInitialValues(); /* * Initialize variables */ cytosol = 1.0; // initial value of $cytosol store = 1.0; // initial value of $store K2 = 1.0; // initial value of K2 Ka = 0.9; // initial value of Ka Kr = 2.0; // initial value of Kr Vm2 = 65.0; // initial value of Vm2 Vm3 = 500.0; // initial value of Vm3 beta = 0.301; // initial value of beta k = 10.0; // initial value of k kf = 1.0; // initial value of kf m = 2.0; // initial value of m n = 2.0; // initial value of n p = 4.0; // initial value of p v0 = 1.0; // initial value of v0 v1 = 7.3; // initial value of v1 } /* * Model variables initial values */ protected double rate_R0; protected double rate_R1; protected double rate_R2; protected double rate_R3; protected double rate_R_eff; protected double rate_Rf; protected double cytosol; protected double store; protected double K2; protected double Ka; protected double Kr; protected double Vm2; protected double Vm3; protected double beta; protected double k; protected double kf; protected double m; protected double n; protected double p; protected double v0; protected double v1; public double[] extendResult(double time,double [] x) { this.time = time; double[] y = new double[2]; y[0] = x[0]; y[1] = x[1]; return y; } public double[] getInitialValues() { double [] x = new double[2]; this.time = 0.0; x[0] = 0.15; // - $"cytosol.Z" x[1] = 1.6; // - $"store.Y" __internalRateVarInitFunc_0(time, x); return x; } /* * code for algebraic rules calculations */ /* * end of code for algebraic rules calculations */ protected void calculateRates(double time, double[] x) { __internalRateVarInitFunc_0(time, x); } /* * calculate dy/dt for 'BIOMD0000000098.xml' model */ public void __internalDyDt_0(double time, double [] x, double[] result) { result[0] = +rate_R0+rate_R1-rate_R2+rate_R3-rate_R_eff+rate_Rf; result[1] = +rate_R2-rate_R3-rate_Rf; } protected double [] calculateResult(double time, double[] x) { double[] result = new double[2]; __internalDyDt_0(time, x, result); return result; } public double[] dy_dt(double time, double[] x) { this.time = time; calculateRates( time,x ); return calculateResult( time,x ); } } // class ...